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KMID : 0370220030470020098
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Yakhak Hoeji
2003 Volume.47 No. 2 p.98 ~ p.103
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Drug Interaction between Flavone and Paclitaxel in Rats
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최준식/Choi JS
이진환/Lee JH
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Abstract
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The purpose of this study was to investigate the effect of flavone (20 mg/kg) on the pharmacokinetic parameters and the bioavailability of paclitaxel (40 mg/kg) orally coadmin istered in rats. The plasma concentration of paclitaxel in combination with flavone was increased significantly (coadministration p<0.05, pretreatment p<0.01) compared to that of control. Area under the plasma concentration-time curve (AUC) of paclitaxel with flavone was significantly (coadministration p<0.05, pretreatment p<0.01) higher than that of control. Peak concentration (Cmax) of paclitaxel with flavone were signnifcantly increased (coadministration p<0.05, pretreatment p<0.01) compared to that of control. Time to peak concentration (Tmax) of paclitaxel with flavone decreased significantly (p<0.05) than that of control. The total body clearance (CLt) and elimination rate constant (β) of paclitaxel with flavone were significantly reduced (p<0.05) compared to those of control. Half-life (t1/2) of paclitaxel with flavone was significantly prolonged (p<0.05) compared to that of control. Based on these results, it might be concluded that flavone may enhance bioavailability of paclitaxel through the inhibition of cytochrome P45O and P-glycoprotein, which are engaged in paclitaxel absorption and metabolism in liver and gastrogintestinal mucosa, respectively.
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